From a recent thread, JoeLucid's experience suggested that at 300kbps you're better off with at least 4 preamble bytes and and at least three sync bytes. Those are greater than the defaults, so you may want to try increasing yours.
Data whitening might help. It's not defaulted either.
Beyond that, what RSSI levels are you getting? Higher speeds need a higher signal-to-noise ratio, so you may want to measure both.
My first guess though: 6" apart sounds too close. You're probably saturating your radios. Try moving them apart to a more reasonable distance, like, say, 10 or 15 feet apart, line-of-sight. That's still close, but not overly so.
My second guess: your FTDI adapters don't supply enough juice. So, when you send packets at a faster pace, that becomes more noticeable, because any caps are draining and not given enough time to refill before the next packet. As a workaround, try powering your moteino's with batteries instead.