I have not personally tried Hifiberry but others did and it worked, see below.The ATXRaspi is just a power switch designed to provide power to RPi with very minimal voltage drop across it.As long as you have a good power supply that can deliver your total Amperage load needed by the Pi+accesories, the ATXRaspi can handle it.See these threads related to Hifiberry and ATXRaspi:https://lowpowerlab.com/forum/atxraspi/atxraspi-not-working-with-volumio/msg18412/#msg18412https://lowpowerlab.com/forum/atxraspi/setup-script-for-atxraspi/msg8148/#msg8148